What is pibrentasvir used for?

Pibrentasvir is an NS5A inhibitor combined with glecaprevir in Mavyret for the treatment of chronic hepatitis C genotypes 1-6. The combination achieves SVR12 rates above 97% in treatment-naive patients with 8 weeks of therapy.

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How to Pronounce Pibrentasvir (Mavyret)

pie-BREN-tas-vir

IPA: /paɪ.ˈbrɛn.tæs.vɪr/

Brand name: Mavyret (with glecaprevir)

pie BREN tas vir

How do you pronounce Pibrentasvir?

Pibrentasvir is pronounced “pie-BREN-tas-vir”. It has 4 syllables: pie – bren – tas – vir. The stress falls on the second syllable, “BREN”. The INN suffix -asvir is shared by all HCV NS5A inhibitors (daclatasvir, ledipasvir, velpatasvir).

How many syllables are in Pibrentasvir?

Pibrentasvir has 4 syllables: pie – bren – tas – vir.

What does Pibrentasvir mean?

Pibrentasvir is a pangenotypic NS5A inhibitor that disrupts hepatitis C virus RNA replication and virion assembly. Co-formulated with glecaprevir as Mavyret (3 tablets once daily with food), it achieves cure (SVR12 >97%) in 8 weeks for treatment-naive patients without cirrhosis across HCV genotypes 1–6. The NS5A suffix -asvir identifies its mechanism class.

Word Parts

pibrentas- unique drug identifier stem

-asvir HCV NS5A inhibitor class (INN suffix)

Common Mispronunciations

Often mispronounced as “pie-bren-TAZ-vir” — the correct stress is on the second syllable: pie-BREN-tas-vir. The ending is “-asvir” not “-azvir”.

Where You’ll Encounter This

Pibrentasvir/glecaprevir (Mavyret) is used in hepatology, infectious disease, and increasingly in primary care for HCV cure. It is preferred in patients with chronic kidney disease because it requires no renal dose adjustment. Resistance-associated substitutions (RAS) in NS5A can reduce efficacy in certain treatment-experienced patients.