What does Glecaprevir treat?

Glecaprevir is a direct-acting antiviral used to treat chronic hepatitis C virus (HCV) infection. It is always combined with pibrentasvir (sold as Mavyret) and is active against all major HCV genotypes (1-6).

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How to Pronounce Glecaprevir (Mavyret)

glek-a-PREV-ir

IPA: /ˌɡlɛk.ə.ˈprɛv.ɪr/

Brand name: Mavyret (with pibrentasvir)

glek a PREV ir

How do you pronounce Glecaprevir?

Glecaprevir is pronounced “glek-a-PREV-ir”. It has 4 syllables: glek – a – prev – ir. The stress falls on the third syllable, “PREV”. The INN suffix -previr is shared by all HCV protease inhibitors (boceprevir, telaprevir, simeprevir).

How many syllables are in Glecaprevir?

Glecaprevir has 4 syllables: glek – a – prev – ir.

What does Glecaprevir mean?

Glecaprevir is a pangenotypic NS3/4A serine protease inhibitor active against HCV genotypes 1 through 6. It is co-formulated with pibrentasvir (an NS5A inhibitor) in Mavyret tablets. The combination achieves sustained virologic response (SVR) rates above 97% in treatment-naive patients with 8 weeks of therapy. It is safe in renal impairment and does not require dose adjustment for kidney disease.

Word Parts

gleca- unique drug identifier stem

-previr HCV NS3/4A protease inhibitor class (INN suffix)

Common Mispronunciations

Often said “GLEE-ka-prev-ir” — the first syllable is “glek” (short e), not “glee”. Correct: glek-a-PREV-ir.

Where You’ll Encounter This

Glecaprevir/pibrentasvir (Mavyret) is the preferred pangenotypic HCV regimen in many guidelines due to 8-week treatment duration for most patients and renal safety. Used in hepatology, infectious disease, and primary care. The combination should be avoided in Child-Pugh B/C cirrhosis due to drug accumulation.