How to Pronounce Naloxone (Narcan)

nal-OX-one
IPA: /næl.ˈɒk.soʊn/
Brand names: Narcan, Evzio, Kloxxado
nal OX one
Naloxone is pronounced nal-OX-one

How do you pronounce Naloxone?

Naloxone is pronounced “nal-OX-one”. It has 3 syllables: nal ‑ ox ‑ one. The stress falls on the second syllable, “ox”.

How many syllables are in Naloxone?

Naloxone has 3 syllables: nal ‑ ox ‑ one.

What does Naloxone mean?

Naloxone is a competitive opioid receptor antagonist that rapidly reverses opioid overdose by displacing opioids from mu, kappa, and delta receptors. It has no agonist activity of its own, so it restores normal respiration without producing euphoria. It is available as a nasal spray (Narcan), auto-injector (Evzio), and IV/IM formulation for clinical use. Due to its short duration of action (30–90 minutes), repeat dosing may be needed for longer-acting opioids like fentanyl.

Word Parts

prefix nal- N-allyl modification of morphine
root -ox- oxymorphinone chemical backbone
suffix -one ketone group in structure

Common Mispronunciations

Often confused with naltrexone and said "nal-TREX-one" — naloxone stresses OX: nal-OX-one

Where You'll Encounter This

Opioid overdose reversal, emergency medicine, harm reduction programs. Short-acting — repeat doses may be needed for long-acting opioids. Combined with buprenorphine in Suboxone.

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